Join an Expedition
 in Cancer Research

Cancer can be isolating, but you’re not facing it alone. Dedicated researchers and a community of people with cancer are coming together to explore a new world of possibilities through clinical research. Consider joining them on this journey by participating in a clinical research study.
Learn more about the AndroMETa Studies.
See If You Prequalify for a Cancer Study
Learn more about the AndroMETa Studies.

An Expedition in Colorectal Cancer, Gastroesophageal Adenocarcinoma, and Non-Small Cell Lung Cancer

What Do These Cancers Have in Common?

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What Is c-Met?1

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What Happens in the Body?2

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Colorectal cancer (CRC), gastroesophageal adenocarcinoma (collectively referred to here as GEA, which includes gastric, gastroesophageal junction, and esophageal adenocarcinomas), and non-small cell lung cancer (NSCLC) are all types of adenocarcinomas. An adenocarcinoma is a type of cancer that starts in the glands that line your organs.

CRC

Click here to learn more about CRC.

GEA

Click here to learn more about GEA.

NSCLC

Click here to learn more about NSCLC.
The c-Met protein (also known as the MET protein) may be found on the surface of cells in solid tumors. Elevated levels of c-Met can cause cells to grow abnormally (in ways they aren’t supposed to), which can cause cancer or make it worse. This increased expression can be found in several solid tumors, including CRC, GEA, and NSCLC.

1 https://www.clinical-colorectal-cancer.com/article/S1533-0028(18)30004-5/fulltext

1 https://www.clinical-colorectal-cancer.com/article/S1533-0028(18)30004-5/fulltext

Cancer occurs when some cells in the body start growing uncontrollably and spreading to other areas. While healthy cells typically divide to replace old or damaged ones, damaged or abnormal cells continue to multiply instead of dying off as they should. This uncontrolled growth can lead to the formation of masses known as tumors, which may be either benign (non-cancerous) or malignant (cancerous).

Cancerous cells may continue to grow abnormally and may eventually spread to different body parts from where they started. This process is called metastasis.

2 https://www.cancer.gov/about-cancer/understanding/what-is-cancer

2 https://www.cancer.gov/about-cancer/understanding/what-is-cancer

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About Solid Tumors

A solid tumor is a mass of tissue that forms when abnormal cells group together and grow uncontrollably. Unlike liquid tumors, which affect the blood and bone marrow, solid tumors develop in organs or tissues. This program explores solid tumors called adenocarcinomas, which grow in the glands that line the organs, such as in the colon, gastroesophageal junction, or lung.
Learn more about each of these conditions below.
Quick Facts on

Colorectal Cancer

  • Colorectal cancer (CRC) is a solid tumor that forms in the colon or the rectum, which are part of the digestive system.1
  • Symptoms can include persistent diarrhea or constipation, cramping, stomach pain, and tiredness.2
  • There were almost 2 million new cases of CRC globally in 2022, making it the third most common cancer worldwide.3
  • Common risk factors for CRC include obesity, smoking, and diets heavy in red and processed meats.4
Quick Facts on

Gastroesophageal Adenocarcinoma

  • Gastric, gastroesophageal junction, and esophageal adenocarcinoma (GEA) are types of cancer that form mostly in the stomach and lower esophagus.5
  • Gastric cancer is the fifth most common cancer worldwide.3
  • There are many possible symptoms, which commonly include difficulty swallowing and weight loss.5
  • Smoking, helicobacter pylori bacterial infection, gastric reflux, and certain gene mutations are among the risk factors for GEA.5
Quick Facts on

Non-Small Cell Lung Cancer

  • Non-small cell lung cancer (NSCLC) is a solid tumor that forms in the tissues of the lung.6
  • Symptoms can include a persistent cough, difficulty breathing, chest pain, and tiredness.6
  • Lung cancer is the most common cancer worldwide, with almost 2.5 million new cases of lung cancer globally in 2022.3
  • The most common risk factors for NSCLC include smoking, exposure to smoke, and a family history of lung cancer.6

What Can Research Do?

Existing treatments for CRC, GEA, or NSCLC may not work for everyone, so many patients continue to seek different options. Researchers are dedicated to exploring new possibilities through clinical research. Join them on this expedition and explore the AndroMETa Studies.
See If You Prequalify for a Cancer Study

1 https://www.cancer.org/cancer/types/colon-rectal-cancer/about/what-is-colorectal-cancer.html

2 https://www.cancer.org/cancer/types/colon-rectal-cancer/detection-diagnosis-staging/signs-and-symptoms.html

3 https://www.wcrf.org/cancer-trends/worldwide-cancer-data/

4 https://www.cancer.org/cancer/types/colon-rectal-cancer/causes-risks-prevention/risk-factors.html

5 https://www.ncbi.nlm.nih.gov/books/NBK6982/

6 https://www.cancer.gov/types/lung/patient/non-small-cell-lung-treatment-pdq

Explore what you can do today.

See If You Prequalify for a Cancer Study
Many patients with metastatic CRC, GEA, or NSCLC with c-MET overexpression are seeking additional treatment options. Researchers are dedicated to opening up new possibilities through clinical research. Join them on this expedition and explore the AndroMETa Studies.
See If You’re Eligible
Colorectal cancer (CRC), gastroesophageal adenocarcinoma (collectively referred to here as GEA, which includes gastric, gastroesophageal junction, and esophageal adenocarcinomas), and non-small cell lung cancer (NSCLC) are all types of adenocarcinomas. An adenocarcinoma is a type of cancer that starts in the glands that line your organs.

CRC

CRC starts in the colon or rectum.

GEA

GEA can start in the stomach, the esophagus, or where the two organs meet—the junction.

NSCLC

NSCLC starts in the lung's tissue